Why Yellow 577?

> Why Yellow 577nm?

The 577nm true yellow wavelength is not actually a new addition to the therapeutic armamentarium in ophthalmology. It was introduced 20 years ago for the treatment of diabetic retinopathy. At that time, it was a favored wavelength among retinal specialists. Unavailable during an entire decade for technological reasons, it has been reintroduced in ophthalmology a couple of years ago with the improved efficiency and the reliability of the solid state technology. Why Yellow 577nm?

> Yellow 577nm Benefits

Theoretically, the 577-nm yellow laser light provides peak absorption of oxyhemoglobin, excellent lesion visibility, low intraocular light scattering and pain, and negligible xanthophyll absorption12. In the literature, the yellow 577nm wavelength has been described as a safe and versatile wavelength:

  • Thanks to its absorption characteristics, it causes lesser scatter and requires the use of a lower energy level compared to green (532nm) and other yellow (561 to 568nm) wavelengths3.
  • It is minimally absorbed by macular xanthophylls45, potentially allowing for treatments close to the fovea6.
  • It is highly absorbed by the oxyhemoglobin (absorption peak) and thus optimal for the treatment of vascular lesions and subretinal vascular proliferations7.
  • It allows an excellent penetration through cataracts8.
Absorption - 577nm Wavelenght

Yellow 577nm Wavelength Benefits
Giovanni Staurenghi,MD

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> Clinical References

  1. Tissue optics, thermal effects, and laser systems.
    Ophthalmology 1986;93:952-8. Mainster MA. Wavelength selection in macular photocoagulation.
  2. Decreasing retinal photocoagulation damage: principles and techniques.
    Semin Ophthalmol 1999;14: 200-9. Mainster MA.
  3. The Short-term Efficacy of SubLiminal® Micropulse Yellow (577-nm) Laser Photocoagulation for Diabetic Macular Edema.
    Korean J Ophthalmol. 2014 Oct;28(5):379-85. doi: 10.3341/kjo.2014.28.5.379. Epub 2014 Sep 18. Kwon YH, Lee DK, Kwon OW.
  4. Tissue optics, thermal effects, and laser systems.
    Ophthalmology 1986;93:952-8. Mainster MA. Wavelength selection in macular photocoagulation.
  5. Macular photocoagulation: optimal wavelength selection.
    Ophthalmology. 1982;89:721- 728. Trempe CL, Mainster MA, Pomerantzeff O, et al.
  6. The Short-term Efficacy of SubLiminalTM Micropulse Yellow (577-nm) Laser Photocoagulation for Diabetic Macular Edema.
    Korean J Ophthalmol. 2014 Oct;28(5):379-85. doi: 10.3341/kjo.2014.28.5.379. Epub 2014 Sep 18. Kwon YH, Lee DK, Kwon OW.
  7. Animal experiments for the determination of an optimal wavelength for retinal coagulations.
    Graefes Arch Clin Exp Ophthalmol. 1989;227:277-280. Vogel M, Schafer FP, Stuke M, Muller K, Theuring S, Morawietz A.
  8. Clinical Experience With Multispot Yellow 577nm Laser.
    Retinal Physician – Sébastien Guigou, Eric Parrat